Premium
BASAL AND HORMONE‐INDUCED URINARY CYCLIC AMP IN CHILDREN WITH RENEL DISORDERS
Author(s) -
MoNN E.,
OSNES J. B.,
ØYE I.
Publication year - 1976
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1976.tb18012.x
Subject(s) - nephrogenic diabetes insipidus , medicine , antidiuretic , diabetes insipidus , endocrinology , basal (medicine) , parathyroid hormone , urinary system , hormone , pseudohypoparathyroidism , urine , vasopressin , diabetes mellitus , calcium
. The excretion of cyclic AMP in urine has been examined in normal children and in children with nephrogenic diabetes insipidus or moderate renal failure (predominantly defective concentrating ability) under basal conditions and in response to antidiuretic hormone (ADH) and parathyroid hormone (PTH). In contrast to other reported data, we could not confirm an ADH‐ and PTH‐unresponsiveness in hereditary, congenital nephrogenic diabetes insipidus, but our patients with structural renal disorders characterized by a defective urine concentrating ability did have reduced hormonal responses. It seems necessary to define nephrogenic diabetes insipidus very carefully, and until more data are collected, there appears to be no value in the measurement of urinary cyclic AMP level in the individual patient in the differential diagnosis of disorders due to renal concentrating defects.