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DEFECTIVE NEUTROPHIL MOTILITY IN HYPOVITAMINOSIS D RICKETS
Author(s) -
LORENTE F.,
FONTAN G.,
JARA P.,
CASAS C.,
GARCIARODRIGUEZ M. c.,
OJEDA J. A.
Publication year - 1976
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1976.tb18005.x
Subject(s) - medicine , hypovitaminosis , rickets , motility , vitamin d and neurology , immunology , vitamin d deficiency , biology , genetics
ABSTRACT. The chemotactic activity and random motility of neutrophils, was studied in 38 patients with hypovitaminosis D rickets, and compared with 29 healthy controls of matched age. The chemotactic activity derived from the activated rickets serum as well as the amounts of the complement components C4, C3 and C5 was normal, but the cell motility was clearly defective (p<0.001). A possible relationship between defective neutrophil movement and the recurrent infections seen in these patients is suggested. The possible mechanisms responsible for the defect could be the alteration in Ca/P metabolism or a defective action of the vitamin D on the neutrophils.