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RENAL FUNCTION AS A MARKER OF HUMAN FETAL MATURATION
Author(s) -
SIEGEL SHARON R.,
OH WILLIAM
Publication year - 1976
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1976.tb04917.x
Subject(s) - medicine , renal function , gestational age , fractional excretion of sodium , gestation , fetus , excretion , endocrinology , creatinine , urinary system , renal physiology , pregnancy , physiology , biology , genetics
. Sixty clinically well infants of various gestational ages (27 to 40 weeks) were studied from 24–40 hours after birth to evaluate glomerular filtration rate and renal excretion rate of sodium at various stages of fetal maturation. Creatinine clearance was directly related to gestational age ( r =0.643). Fractional sodium excretion was inversely related to gestational age ( r =‐0.755). The renal functions of small for gestational age infants were similar to those of full‐term infants whose birth weights were appropriate for gestational age. The data showed that the glomerular functions of an infant below 32 weeks of gestation were more predominant than the tubular function resulting in a greater fractional sodium excretion rate and higher urinary Na loss in infants of this gestational age, when compared with the more mature infants.