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FAMILIAL OCCURRENCE OF CEREBRAL GIGANTISM, SOTOS' SYNDROME
Author(s) -
HANSEN F. JUUL,
FRIIS BIRGITTE
Publication year - 1976
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1976.tb04902.x
Subject(s) - gigantism , sotos syndrome , medicine , etiology , pediatrics , acromegaly , endocrinology , growth hormone , hormone
. Since the original description of cerebral gigantism, about 85 cases have been reported. Four papers comment on familial occurrence but never in parents and their children. This paper describes the syndrome in a mother and her child, which, together with facts pointing towards prenatal etiology, such as excessive birthweight, striking mutual resemblance and abnormal dermatoglyphics, points to a genetic defect. Previous endocrine studies are enlarged by the findings of normal serum somatomedin and serum prolactin.