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TREATMENT OF IDIOPATHIC AUTOIMMUNE HEMOLYTIC ANEMIA IN CHILDREN Review and Report of Two Fatal Cases in Infancy
Author(s) -
JOHNSON CHRISTINE A.,
ABILDGAARD CHARLES F.
Publication year - 1976
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1976.tb04900.x
Subject(s) - medicine , autoimmune hemolytic anemia , azathioprine , splenectomy , cyclophosphamide , thymectomy , pediatrics , anemia , hemolytic anemia , disease , clinical trial , autoimmune disease , surgery , myasthenia gravis , chemotherapy , spleen
. Report of two cases of severe idiopathic autoimmune hemolytic anemia (AIHA) in infants who underwent splenectomy and received corticosteroids and cyclophosphamide without benefit. One infant, additionally, was treated with thymectomy and azathioprine without influencing his disease. Experience of therapy for childhood AIHA is reviewed. Four children with AIHA have been thymectomized. Two of these failed to benefit from surgery. There have been fifteen previous trials with immunosuppressive agents in childhood AIHA. About 60% of the children so treated (9 of 15) have shown improvement. Additional clinical trials with this agent are warranted.