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IMMUNOGLOBULIN LEVELS IN CHILDREN WITH HOMOZYGOUS β‐THALASSEMIA
Author(s) -
VALASSIADAM HELEN,
NASSIKA EVANGELIA,
KATTAMIS CHRISTOS,
MATSANIOTIS NICOLAS
Publication year - 1976
Publication title -
acta paediatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1976.tb04402.x
Subject(s) - medicine , antibody , hemosiderosis , thalassemia , immunology , immunoglobulin g , immunoglobulin m , pediatrics
. Patients with hereditary hemolytic anaemias have been known to have immunoglobulin alterations related to an increased susceptibility to infection. In the present series, immunoglobulins G, A and M have been estimated in 50 thalassemic children aged 10 months to 13 years. No significant difference was found in any of the immunoglobulins between patients and age‐matched controls. No correlation could be shown between immunoglobulin levels and ( a ) the severity of anaemia, ( b ) the degree of hemosiderosis, and ( c ) the frequency of febrile infections per year. Against clinical impressions patients did not show any increased susceptibility to infections.