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ACUTE LIVER FAILURE AND ENCEPHALOPATHY (REYE'S SYNDROME?) DURING SALICYLATE THERAPY
Author(s) -
SILLANPÄÄ MATTI,
MÄKELÄ ANNALIISA,
KOIVIKKO ANTTI
Publication year - 1975
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1975.tb03941.x
Subject(s) - medicine , reye's syndrome , reye syndrome , encephalopathy , etiology , gastroenterology , hepatic encephalopathy , transaminase , biochemistry , enzyme , cirrhosis , chemistry
Sillanpää, M., Mäkelä, A.‐L. and Koivikko, A. (Department of Paediatrics, University of Turku, Turku, Finland). Acute liver failure and encephalopathy (Reye's syndrome?) during salicylate therapy. Acta Paediatr Scand, 64: 877, 1975.–A case of hepatotox‐icity and encephalopathy (Reye's syndrome?) associated with salicylate therapy is presented and the aetiology of this syndrome is discussed. Hepatotoxicity developed with salicylate serum concentrations not exceeding therapeutic serum levels. The importance of controlling serum salicylate concentration and transaminase activity particularly during the first fourteen days of therapy is emphasized.