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SYSTEMIC ALLERGIC REACTION TO INITIAL INSULIN THERAPY IN A JUVENILE DIABETIC
Author(s) -
DACOUVOUTETAKIS C.,
THOMAIDIS TH.,
ROMA E.,
KALPINIMAVROU A.,
ECONOMOUMAVROU C.
Publication year - 1975
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1975.tb03920.x
Subject(s) - medicine , insulin , diabetes mellitus , allergy , allergic reaction , sensitization , endocrinology , immunology
Dacou‐Voutetakis, C. Thomaidis, Th., Roma, E., Katpini‐Mavrou, A. and Economou‐Mavrou, C. (First Department of Paediatrics, Athens University, Greece). Systemic allergic reaction to initial insulin therapy in a juvenile diabetic. Enhanced blast transformation to insulin. Acta Paediatr Scand, 64: 773, 1975–A 14‐year‐old girl with recent onset of diabetes developed a severe systemic allergic reaction to beef‐pork insulin on the third day of insulin therapy. The same reaction developed following the injection of pork insulin and monocomponent insulin. The patient was induced to tolerate pork insulin by systemic de‐sensitization to this insulin over an interval of 6 days. Peripheral blood lymphocytes from the patient cultured in the presence of insulin responded by increased blast cell transformation, as compared with controls, who either had previously presented local allergic reactions to insulin or never had manifested insulin allergy.