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OXYGEN AFFINITY OF HAEMOGLOBIN AND RED CELL 2,3‐DIPHOSPHOGLYCERATE IN CHILDHOOD DIABETES
Author(s) -
DITZEL J.,
ANDERSEN H.,
PETERS N. DAUGAARD
Publication year - 1975
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1975.tb03846.x
Subject(s) - diphosphoglycerate , medicine , red cell , endocrinology , diabetes mellitus , metabolic control analysis , hemoglobin
Ditzel, J., Andersen, H. and Daugaard Peters, N. (Section of Endocrinology, Department of Medicine, Department of Paediatrics and Department of Clinical Chemistry, Aalborg Regional Hospital, Aalborg, Denmark). Oxygen affinity of haemoglobin and red cell 2,3‐diphosphoglycerate in childhood diabetes. Acta Paediatr Scand, 64:355, 1975.–Red cell 2,3‐diphosphoglycerate (2,3‐DPG) and the oxygen haemoglobin dissociation curve (ODC) were determined in 32 ambulatory, non‐acidotic diabetic children and in 49 healthy children. Despite the fact that the diabetic children had, on average, an increased haemoglobin concentration, their erythrocytes contained significantly more 2,3‐DPG than normal. Both in diabetic and in healthy children a negative relationship was found between the content of 2,3‐DPG and the haemoglobin concentrations. No relationship was present between the plasma glucose and the 2,3‐DPG concentration. The concentration of plasma inorganic phosphate (Pi) in the diabetic children was significantly higher than in the control children, and for all children there was a significant relationship between the 2,3‐DPG and the Pi. In the diabetics 2,3‐DPG was positively correlated to the P 50 (7·40) and to the P 50 (in vivo pH) of the ODC. However, despite the significant increase in 2,3‐DPG among the diabetic children the average P 50 (7·40) and P 50 (in vivo pH) was not increased as compared with the control children. The inhibitory factor preventing the oxygen affinity from decreasing among the diabetics was strongly correlated to an increase in the mean corpuscular haemoglobin concentration. The result of this study suggests the presence of an increased amount of a haemoglobin fraction with high oxygen affinity (haemoglobin A lc ) in the red cells of juvenile diabetics.