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ADDITIONAL DATA ON HEPATIC FUNCTION TESTS IN CYSTIC FIBROSIS
Author(s) -
FEIGELSON J.,
PECAU YVETTE,
CATHELINEAU LILIANE,
NAVARRO J.
Publication year - 1975
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1975.tb03844.x
Subject(s) - medicine , cholestasis , cirrhosis , cystic fibrosis , gastroenterology , cytolysis , liver function tests , fibrosis , pathology , biology , biochemistry , cytotoxic t cell , in vitro
Feigelson, J., Pecau, Y., Cathelineau, L. and Navarro, J. (49, Bd Bessieres 75‐Paris XVIIO, France). Additional data on hepatic function tests in cystic fibrosis. Acta Paediatr Scand 64:337, 1975.–Fifty cystic fibrosis (CF) patients, of whom 9 had multilobular cirrhosis, were observed regularly for a period of 3 years and various liver function tests, indicating cytolysis, cholestasis and cellular insufficiency were performed. Immunoglobulin and prothrombin were assayed. In 9 patients with cirrhosis, the tests were generally abnormal. Two distinct biochemical patterns of cirrhosis were distinguished, one clearly cholestatic and the other of a more cellular type. The distinction was made on the basis of the IgA: Transferrin ratio and of gamma‐glutamyl‐transpeptidase levels. In the non‐cirrhotic patients, a temporary increase of cytolysis and cholestasis was observed in 50 % of the cases.