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ENDOCRINOLOGICAL ASPECTS AT FOLLOW‐UP STUDIES IN NEONATAL HYPOGLYCAEMIA
Author(s) -
FLUGE G.,
STØA K. F.,
AARSKOG D.
Publication year - 1975
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1975.tb03835.x
Subject(s) - medicine , tolbutamide , insulin , hypoglycemia , hyperinsulinism , diabetes mellitus , endocrinology , pediatrics , insulin response , family history , hormone , insulin resistance , plasma glucose
Fluge, G., Støa, K. F. and Aarskog, D. (Department of Paediatrics and Hormone Laboratory, University of Bergen, Bergen, Norway). Endocrinological aspects at follow‐up studies in neonatal hypoglycaemia. Acta Paediatr Scand, 64: 280, 1975.–Thirty‐seven cases of neonatal hypoglycaemia were studied at follow‐up at the age of 2 6/12 ‐ 4 9/12 years. Two of them had had hypoglycaemia after the newborn period, and another patient died in a hypoglycaemic state following surgery at 10 weeks of age. Twenty‐three children had oral glucose tolerance tests and intravenous insulin tolerance tests performed. Diabetic glucose tolerance was noted in 3 children. None of them showed symptoms of diabetes mellitus, neither was there any family history of diabetes. One of these patients had experienced hypoglycaemia after the newborn period and responded with hyperinsulinism during the glucose tolerance test. The other hypoglycaemic patient showed an exaggerated insulin release in response to tolbutamide. Deficient serum Cortisol response to insulin‐induced hypoglycaemia was demonstrated in 7 patients and 6 of these had concomitant minimal growth hormone response. One of these patients also had a diabetic glucose tolerance. None were of short stature. It is probable that a disturbance in the hypothalamic‐pituitary‐adrenal axis may contribute to an impaired carbohydrate metabolism in some patients with neonatal hypoglycaemia.