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ABSENCE OF INSULIN RESISTANCE IN 4 CASES OF MILD JUVENILE DIABETES
Author(s) -
THORELL J. I.,
NILSSON K. O.,
HAGER A.
Publication year - 1975
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1975.tb03829.x
Subject(s) - medicine , insulin , diabetes mellitus , insulin resistance , juvenile , endocrinology , biology , genetics
Thorell, J. I., Nilsson, K. O. and Häger, A. (Departments of Nuclear Medicine and Paediatrics, University Clinics, General Hospital, Malmö and the Department of Paediatrics, University Hospital, Linköping, Sweden). Absence of insulin resistance in 4 cases of mild juvenile diabetes. A preliminary report. Acta Paediatr Scand 64:248, 1975. –Four children with a mild non‐insulin‐requiring diabetes were studied. They had no insulin response at intravenous glucose tolerance test. When insulin was infused at a rate which simulated a normal early insulin response to intravenous glucose, blood glucose decreased to the same extent as it did in healthy subjects. When a normal early insulin response was simulated during the intravenous glucose tolerance test, the glucose assimilation rate was normalized. These results suggests that a peripheral resistance to insulin is unlikely in mild juvenile diabetes, and that the primary defect is a deficient release of insulin.