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ENHANCEMENT OF FAT ELIMINATION DURING INTRAVENOUS FEEDING
Author(s) -
FORGET P. P. F. X.,
FERNANDES J.,
BEGEMANN P. HAVERKAMP
Publication year - 1974
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1974.tb17000.x
Subject(s) - medicine , lipase , lipoprotein lipase , triglyceride , erasmus+ , lipoprotein , endocrinology , cholesterol , enzyme , biochemistry , adipose tissue , art , chemistry , the renaissance , art history
. Forget, P. P. F. X., Fernandes, J. and Haverkamp Begemann, P. (Department of Paediatrics, Sophia Children's Hospital and Neonatal Unit, Erasmus University, Rotterdam, the Netherlands). Enhancement of fat utilization during prolonged intravenous feeding. AdaPaediatrScand, 63:750, 1974.‐An 8‐year‐old girl with severe underweight caused by anorexia nervosa was treated with total intravenous nutrition for 4 weeks. During this period the Intralipid dose was stepwise increased, the doses of Vamin and glucose were kept constant. The Intralipid dose was monitored by the determination of the serum Intralipid levels. The fat utilization was investigated by intravenous fat tolerance tests and the estimation of postheparin lipoprotein lipase activity of the plasma. The Intralipid elimination constant increased from 796 to 2296/min, the postheparin lipoprotein lipase activity increased from 50 to 317 μEq fatty acid/min/l. These data enabled us to increase the Intralipid dose from 3 g fat/kg/per day to 8 g fat/kg/per day, without an increase of the triglyceride blood levels. We may conclude that lipoprotein lipase is an inducible enzyme. It is not clear which component of the hyper‐caloric intravenous regime causes this induction.