Premium
ASYMMETRIC TESTICULAR DYSGENESIS
Author(s) -
RYBAK M.,
SOKLOWSKI J.,
SZMIGIEL C.,
KLECZKOWSKA A.,
NOWICKI Z.,
PILCH J.
Publication year - 1974
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1974.tb04883.x
Subject(s) - medicine , gonadal dysgenesis , dysgenesis , malignancy , gynecology , karyotype , histology , pediatrics , endocrinology , anatomy , biology , biochemistry , gene , chromosome
. Rybak, M., Sokolowski, J., Szmigiel, C., Kleczkowska, A., Nowicki, J. and Pilch, J. (Paediatric Institute and Institute of Anatomy and Histology, Medical Academy, Cracow, Poland). Asymmetric testicular dysgenesis. Acta Paediatr Scand, 63: 889, 1974.—An 8‐months‐old child with abnormal sexual development and male karyo‐type is described. On the basis of clinical, histological and cytogenetic investigations a diagnosis of asymmetric testicular dysgenesis has been established. The abnormalities in gonadal development are probably the result of inadequate and delayed action of inducing substance in early embryonic life. In accordance with the appearance of the external genitalia and the karyotype, male sex has been accepted. It seems reasonable to remove the female rudiments because of a high percentage of malignancy in these cases. Therapy with androgens will be necessary at the time of puberty.