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PSEUDOMONAS AERUGINOSA INFECTION IN CYSTIC FIBROSIS: Occurrence of Precipitating Antibodies against Pseudomonas Aeruginosa in Relation to the Concentration of Sixteen Serum Proteins and the Clinical and Radiographical Status of thi Lungs
Author(s) -
HØIBY NIELS,
JACOBSEN LARS,
JØRGENSEN BIRGIT A.,
LYKKEGAARD ERLING,
WEEKE BENT
Publication year - 1974
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1974.tb04874.x
Subject(s) - pseudomonas aeruginosa , precipitin , cystic fibrosis , medicine , respiratory tract , antibody , pseudomonas infection , respiratory system , immunology , respiratory tract infections , pseudomonas , microbiology and biotechnology , bacteria , biology , genetics
, Heiby, N., Jacobsen, L., Jergensen, B. A., Lykkegaard, E. and Weeke, B. (Statens Seruminstitut, Department of Clinical Microbiology at Blegdamshospitalet, the Paediatric Clinic TG with the Paediatric Clinic of Dronning Louises Børnehospital, the Radiologic Department TX, Rigshospitalet, and the Protein Laboratory, Untversity of Copenhagen, Copenhagen, Denmark). Pseudomonas aeruginosa infection in cystic fibrosis. Acta Paediatr Scand, 63: 843, 1974.—The significance of Pseudomonas aeruginosa infection in the respiratory tract of 9 cystic fibrosis patients have been studied by means of immunoelectrophoretical analysis of patients' sera for the number of precipitins against Pseudomonas aeruginosa and the concentrations of 16 serum proteins. In addition, the clinical and radiographical status of the lungs have been evaluated using 2 scoring systems. Precipitins against Pseudomonas aeruginosa were demonstrated in all sera, the maximum number in one serum was 22. The concentrations of 12 of the serum proteins were significantly changed compared with matched control persons. Notably IgG and IgA were elevated and the “acute phase proteins” were changed, the latter suggesting active tissue damage. The concentrations of 3 of the acute phase proteins, notably haptoglobin were correlated to the number of precipitins suggesting that the respiratory tract infection in patients with many precipitins is accompanied by more tissue damage than the infection in patients with few precipitins. The results indicate no protective value of the many precipitins on the tissue of the respiratory tract.