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THE TRANSCAPILLARY ESCAPE RATE OF T‐1824 IN NEWBORN INFANTS OF DIABETIC MOTHERS AND NEWBORN INFANTS WITH RESPIRATORY DISTRESS OR BIRTH ASPHYXIA
Author(s) -
INGOMAR C. JOH.,
KLEBE J. G.
Publication year - 1974
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1974.tb04848.x
Subject(s) - medicine , asphyxia , respiratory distress , asphyxia neonatorum , diabetes mellitus , pediatrics , respiratory rate , respiratory system , obstetrics , anesthesia , heart rate , blood pressure , endocrinology
. Ingomar, C. Joh. and Klebe, J. G. (Diabetes Center of the Royal Maternity Hospital and the University Department for Newborn Infants, Rigshospitalet, Copenhagen, Denmark). The transcapillary escape rate of T‐1824 in newborn infants of diabetic mothers and newborn infants with respiratory distress or birth asphyxia. Acta Paediatr Scand, 63: 565, 1974.—The influence of certain clinical conditions (idiopathic respiratory distress, birth asphyxia and diabetic embryopathy) on the transcapillary escape rate of human albumin, was investigated in 52 newborn infants. The dyestuff T‐1824 (Evan's blue) was used for the labelling of plasma albumin in vivo, and its plasma concentration was determined spectrophotometrically using a micro‐method. From serial measurements carried out during the first hour following the injection of T‐1824, the escape rate (%/hour) was calculated. Among healthy newborn infants the escape rate was found to increase proportional to the magnitude of the placental transfusion. The same applied to infants with respiratory distress and infants of diabetic mothers, the escape rate of whom did not differ from that of healthy infants. By contrast, the escape rate of albumin was, among some cases of birth asphyxia, found to be increased out of proportion to the placental transfusion, which the infants had received. It is discussed whether the increased escape rate found in these cases is caused by an increased capillary permeability or an increased capillary surface area.