Premium
PHOTOSENSITIZED SHIFT IN THE O 2 DISSOCIATION CURVE OF FETAL BLOOD
Author(s) -
OSTREA ENRIQUE M.,
ODELL GERARD B.
Publication year - 1974
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1974.tb04807.x
Subject(s) - fetus , oxygen–haemoglobin dissociation curve , medicine , andrology , nucleated red blood cell , fetal hemoglobin , hemoglobin , dissociation (chemistry) , physiology , pregnancy , chemistry , biology , genetics
. Ostrea, E. Jr., and Odell, G. (Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA). Photosensitized shift in the O 2 dissociation curve of fetal blood. Acta Paediatr Scand, 63: 341, 1974.–The exposure of fetal erythrocytes to blue light in the presence of bilirubin was associated with a significant decrease in the affinity of fetal cells for O 2 , (δP 50 ) at pH 7.4=+3.17± 0.68 mmHg. This change was not observed with either adult erythrocytes or hemolysates of fetal and adult red cells. Associated with the shift in P 50 , there was a decrease in the Na + , K+ ‐ATP'ase of the irradiated erythrocytes and no electrophoretic evidence of alteration in the fetal hemoglobin. The results suggest that the shift in the O 2 dissociation curve represents an additional manifestation of photodynamic membrane injury and the stroma of fetal erythrocytes influence their oxygen affinity.