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PLASMA INSULIN AND BLOOD GLUCOSE DURING LONG‐TERM TREATMENT WITH DIAZOXIDE FOR INFANT HYPOGLYCEMIA
Author(s) -
VICTORIN LARS H.,
THORELL JAN I.
Publication year - 1974
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1974.tb04802.x
Subject(s) - diazoxide , medicine , hypoglycemia , insulin , pediatrics , endocrinology , side effect (computer science) , computer science , programming language
. Victorin, L. H. and Thorell, J. (Department of Paediatrics, University of Göteborg, Göteborg, and the Isotope Laboratory, Lund University at the General Hospital, Malmö, Sweden). Plasma insulin and blood glucose during long‐term treatment with diazoxide for infant hypoglycemia. Acta Paediat Scand, 63: 302, 1974.–Hypoglycemia of varying etiology is a mayor therapeutic problem in infancy and childhood. It has been shown that diazoxide may increase blood glucose, presumably mainly by prevention of excess insulin release from the pancreas. A case is reported where diazoxide has been used for more than three years in a boy with neurological symptoms due to severe idiopathic hypoglycemia with leucine intolerance where dietary treatment had proved insufficient. A profound improvement in blood glucose level and suppression of pathologic insulin response to both glucose and leucine loads was noted with a diazoxide dose of 15 mg/kg/day which, however, had to be abandoned due to side effects. Over a period of months without diazoxide, insulin responses to glucose and leucine loads progressively increased with recurrence of clinical symtoms. Over the last three years a dose of 5 mg/kg/day has proved effective in keeping clinical symptoms down without side effects. During these years a marked improvement has taken place in neurological, mental and physical development. It is concluded that when due consideration is given to known side effects diazoxide is a valuable adjuvant for long‐term treatment of infantile hypoglycemia.