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PLATELET FUNCTIONS IN CHILDREN WITH CONGENITAL HEART DISEASE
Author(s) -
GOLDSCHMIDT B.
Publication year - 1974
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1974.tb04795.x
Subject(s) - medicine , platelet , heart disease , in vivo , platelet aggregation , bleeding time , clot retraction , platelet adhesiveness , cardiology , surgery , microbiology and biotechnology , biology
. Goldschmidt, B. (Second Department of Paediatrics, Semmelweis Medical University, Budapest, Hungary). Platelet functions in children with congenital heart disease. Acta Paediat Scand, 63 271, 1974.–Examinations of platelet functions (bleeding time, capillary resistance, clot retraction, thrombocyte adhesiveness in vitro and in vivo, spontaneous platelet aggregation, ADP and collagen induced platelet aggregation) were performed in children with CHD. In the cases with acyanotic heart disease (30 cases) the platelet functions were normal. The majority of cases with cyanotic CHD (35 cases) are thrombocytopenic. In these cases protracted bleeding time, increased capillary fragility and reduced clot retraction may be 'observed. The pathologic symptoms are connected with the low number of platelets. In patients with cyanotic CHD the platelet adhesiveness shows in vitro and in vivo a statistically significant increase. In one third of cases, platelet aggregation is also increased in cyanotic patients. Following the administration of ADP and collagen the aggregation shows a normal course.