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INHERITANCE
Author(s) -
Oliver W. Layton
Publication year - 1973
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1973.tb14728.x
Subject(s) - citation , inheritance (genetic algorithm) , medicine , information retrieval , world wide web , genetics , computer science , biology , gene
Most investigators of the inheritance of von Willebrand's disease have arrived at the conclusion that the disease is autosomal dominant (von Willebrand, Jiirgens & Dahlberg 1934, Matter et al. 1956, Nilsson. Blomback & von Francken 1957, Gross & Mammen 1958, Raccuglia & Nee1 1960, Achenbach 1960, Eriksson et al. 1961, Barrow & Graham 1964, Marx & Jean 1964. Cornu 1965). Some authors, however, claim to have found families, where the disease appears to be transmitted by a recessive gene, because neither of the parents of the children affected had shown signs of the disease (Schulman et al. 1955, Verstraete 1963 and Quick 1967:a). Singer and Ramot (1956) reported that several affected children had been born in consanguineous marriages without demonstrable evidence of haemorrhagic disease in the parents. Cornu (1959) made an analysis of the literature and found that of 60 probands with a probable diagnosis of von Willebrand's disease, 4 had consanguineous parents compared with at most one expected. These findings could support the opinion, that the disease is sometimes inherited recessively.