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DISPLACEMENT OF ALBUMIN‐BOUND BILIRUBIN BY INJECTABLE DIAZEPAM PREPARATIONS IN VITRO
Author(s) -
BRATLID DAG,
LANGSLET ASBJØSRN
Publication year - 1973
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1973.tb08146.x
Subject(s) - preservative , medicine , albumin , bilirubin , diazepam , in vitro , chromatography , displacement (psychology) , anesthesia , pharmacology , biochemistry , chemistry , food science , psychology , psychotherapist
Summary Three injectable diazepam preparations, Va‐lium®, Stesolid®, and Vivala® were tested for their ability to displace bilirubin from albumin in vitro. Both Valium® and Stesolid® caused marked displacement of bilirubin and this effect was potentiated by a reduction in pH. Both these diazepam preparations contain benzoate in the buffer preservative. Vivala, which does not contain benzoate in the buffer preservative, did not show any displacement at pH 7.4 and had only a slight effect at pH 6.8.