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URINE ELIMINATION OF AN ORAL SALT AND FLUID LOAD IN HEALTHY CHILDREN
Author(s) -
BERG U.
Publication year - 1973
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1973.tb08145.x
Subject(s) - medicine , urine , sodium , excretion , urinary system , diuresis , endocrinology , urine sodium , renal function , concomitant , chemistry , organic chemistry
Summary A method for studying renal response to an oral sodium and fluid load has been tested in a group of normal children aged 8 to 14 years. An oral sodium load of 80 mEq/1.73BSA was given after water diuresis was induced. Urine wascollectedhourlybyspontaneous voiding. At the time of the study the glomer‐ular filtration rate and clearance of PAH was determined by the single injection technique. After the salt load was given the urinary sodium excretion was increased for 2 hours. Thereafter it reached a fairly stable level which was maintained at least during the next 4 hours. This response was a concomitant finding in all the children studied. It was thereafter considered justified to estimate the renal response to the salt load as the mean urinary sodium excretion from the third to the sixth hour after sodium administration. The urinary sodium excretion was then found to be 16 ± 1.8 mEq/hr/1.73BSA. When the salt load was doubled the urinary sodium excretion was increased by a factor of 1.6. Various explanations for this deviation from complete dose‐response are discussed. It is suggested that the test is used in the evaluation in the control of sodium homeostasis in patients with renal and circulatory disturbances.