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STUDIES IN CYSTIC FIBROSIS 1: Urinary Excretion of Hexosamine, Sialic Acid and Fucose
Author(s) -
KOLLBERG H.,
LUNDBLAD A.,
EKBOHM G.
Publication year - 1973
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1973.tb08104.x
Subject(s) - fucose , sialic acid , excretion , urine , medicine , carbohydrate , neuraminic acid , creatinine , urinary system , fractionation , endocrinology , biochemistry , chromatography , galactose , chemistry
Summary Normal values for the total urinary excretion of hexosamine, sialic acid and fucose and their ratios to creatinine in childhood were determined. The excretion of these substances in 25 CF children was slightly higher at all ages than in controls. The increase was more pronounced in higher ages and in more severely affected patients. No difference in the ratio of fucose to sialic acid was found between controls and CF patients, either in the unfractionated urine or in the ultrafiltrable or non‐ultrafiltrable fractions of urine. Zone electrophoretic fractionation of the non‐ultrafiltrable material disclosed a proportionately higher excretion of both carbohydrate‐ and protein‐containing material in CF patients as compared with controls. Two CF patients exhibited normal gel‐chromatographic distributions of fucose‐con‐taining low molecular weight carbohydrate material.