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FIBRINOLYTIC ACTIVITY IN LUNG TISSUE FROM NEONATES WITH HYALINE MEMBRANE DISEASE
Author(s) -
EKELUND H.,
PANDOLFI M.,
ÖSTBERG GÖREL,
BJERNSTAD A.
Publication year - 1973
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1973.tb08083.x
Subject(s) - hyaline , medicine , atelectasis , lung , pathology , membrane , plasminogen activator , biology , biochemistry
Summary The fibrinolytic activity of lung tissue was studied with Todd's histochemical method in a material of 29 newborn infants containing normal lungs, hyaline membrane disease, atelectasis and massive pulmonary haemorrhage. No significant difference was found between a group of hyaline membrane lungs and a group of atelectatic lungs without hyaline membranes. In one case with massive pulmonary haemorrhage the activity was high. Our findings make it questionable whether a lack of plasminogen activator in the lung of infants with hyaline membrane disease is a consistent finding and argue against an alteration of the intrapulmonary fibrinolytic system being of any major importance in the formation of the membranes.