Premium
PROTHROMBIN IN NEWBORNS AND DURING THE FIRST YEAR OF LIFE
Author(s) -
NOREN I.,
CARLSSON E.,
KRETZSCHMAR G.,
TEGERNILSSON A.C.
Publication year - 1971
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1971.tb06656.x
Subject(s) - medicine , prothrombin time , vitamin k , hematocrit , gastroenterology
Summary Prothrombin concentration, determined specifically with a new two‐stage method, was compared with thrombotest activity in samples from infants, aged 0–21 days. There was a significant correlation between the two methods. Effect of treatment with vitamin K and plasma was registered with both methods. As the distribution of prothrombin and thrombotest values from normal, full‐term neonates was slightly skew, mean value and S.D. was calculated from the logarithmic values. The normal range, expressed as mean ± 2 S.D. was for prothrombin 26–85 % and for thrombotest 27–74% (values corrected for hematocrit). No bleeding was observed in any patient with prothrombin above 20% and thrombotest above 22% (corrected values). Most low values in newborns were found in children suffering from hypoxia. Prothrombin concentration was also compared with prothrombin‐proconvertin activity in samples from children, aged 0–12 months. In the healthy child prothrombin values reached the normal adult level at the age of 6–12 months, prothrombin‐proconvertin values at the age of about 3 months.