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THE COMBINED XYLOSE‐DISACCHARIDE TOLERANCE TEST: ITS APPLICATION FOR DIAGNOSING DISACCHARIDASE DEFICIENCY
Author(s) -
FERNANDES J.,
KAMER J. H.
Publication year - 1971
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1971.tb06640.x
Subject(s) - disaccharidase , xylose , lactose , disaccharide , sucrase , medicine , monosaccharide , sucrose , biochemistry , endocrinology , food science , chemistry , enzyme , small intestine , fermentation
Summary Six children with a sucrase‐isomaltase deficiency were subjected to an oral tolerance test with sucrose or lactose combined with d (+)‐xylose. Simultaneous determination of a xylose curve allowed a more certain interpretation of the blood glucose curve. A flat glucose curve combined with a normal xylose rise points to an impaired enzymic hydrolysis rather than to a defective absorption of its component monosaccharides. Compared with the normal range ±2 S.D. derived from 90 xylose curves of 61 “normal” children, the sucrase‐isomaltase deficients showed normal xylose curves.