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LYMPHOBLASTIC TRANSFORMATION, CHROMOSOME PATTERN AND DELAYED‐TYPE SKIN REACTION IN ATAXIA TELANGIECTASIA
Author(s) -
SCHULER D.,
SCHöNGUT L.,
CSERHATI E.,
SIEGLER J.,
GÁCS G.
Publication year - 1971
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1971.tb06619.x
Subject(s) - ataxia telangiectasia , medicine , malignancy , transformation (genetics) , malignant transformation , chromosome , lymphoblastic leukemia , karyotype , ataxia , pathology , gastroenterology , genetics , dna , biology , leukemia , dna damage , psychiatry , gene
Summary In 6 patients suffering from ataxia telangiectasia morphological evaluation of lymphoblastic transformation was performed; in one of these cases it was repeated four times. In 3 cases the incorporation of 3 H‐thymidine was measured to examine the degree of the lymphoblastic transformation. Both methods revealed decreased lymphoblastic transformation, though with the last method the decrease was much greater. No correlation was found between the degree of decreased blastic transformation, the infections and the plasma IgA level. Delayed‐type skin reactions were subnormal in varying degrees. Increased frequency of chromosome breakage was observed in 1 case–who developed malignancy and died– but no chromosomal aberrations were found in the three other cytogenetically examined patients.