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L‐ASPARAGINASE TREATMENT OF ACUTE LEUKAEMIA IN CHILDREN
Author(s) -
VAAN G. A. M.,
BAKKEREN J. A. J. M.,
SCHRETLEN E. D. A. M.,
REERINK H.
Publication year - 1971
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1971.tb06613.x
Subject(s) - medicine , prednisone , asparaginase , pediatrics , shock (circulatory) , leukemia , lymphoblastic leukemia
Summary The results of asparaginase‐prednisone therapy in children are reported. In 12 children with untreated acute lymphoblastic leukaemia 9 remissions were obtained, there were 2 failures and in one patient therapy had to be stopped because of an anaphylactic shock. One child with an acute myelocytic‐granulocytic type of acute leukaemia did not respond. One child with an acute monocytic‐monoblastic leukaemia was given asparaginase only. He responded very well. Four patients with a relapse of an acute myeloblastic leukaemia were treated: there were two failures, one child died too early from an infection to be evaluated. One child showed a very good reaction. Serious side‐effects were few, the drugs gave many biochemical disturbances including a constant hypofibrino‐genaemia, but these were well tolerated and reversible.