Premium
THE ELECTROLYTE AND PROTEIN CONTENTS AND OUTPUTS IN DUODENAL JUICE AFTER PANCREOZYMIN AND SECRETIN STIMULATION IN NORMAL CHILDREN AND IN PATIENTS ITH CYSTIC FIBROSIS. 1
Author(s) -
ZOPPI G.,
SHMERLING D. H.,
GABURRO D.,
PRADER A.
Publication year - 1970
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1970.tb17707.x
Subject(s) - secretin , medicine , endocrinology , bicarbonate , stimulation , secretion , calcium , potassium , sodium , cystic fibrosis , amylase , chemistry , biochemistry , enzyme , organic chemistry
SUMMARY The total pancreatic outputs and the secretion rates of fluid volume, protein, bicarbonate, sodium, potassium, calcium and magnesium were studied after pancreozymin and secretin stimulation in 12 control children and in 5 patients with cystic fibrosis of the pancreas (CF). Duodenal contents were collected through a double‐balloon, triple‐lumen rubber tube, thus avoiding contamination by gastric juce and distal losses. In CF patients, compared to the normal controls, decreased outputs of fluid volume, protein and electrolytes were found. Secretion rates, calculated per kg body weight and per min of fluid volume protein and electrolytes were analyzed separately for the post‐pancreozymin and the post‐secretin periods. In control children the secretion rates of sodium aad bicarbonate were higher after secretin stimulation, whereas those of protein, calcium, and magnesium were higher after pancreozymin stimulation; secretion rates of fluid volume and potassium did not show any significant difference. In CF patients the secretion rates of sodium, potassium and magnesium were more reduced after secretin whereas those of calcium and protein are more reduced after pancreozymin; the secretion rates of fluid volume and bicarbonate are similarly reduced after both hormonal stimulation. The possible role of a disturbance of the tubular and the acinar secretion of the pancreas in the pathogenesis of cystic fibrosis is discussed.