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A DOUBLE BLIND STUDY OF THE EFFECT OF PHENOBARBITONE ON NEONATAL HYPERBILIRUBINAEMIA AND FREQUENCY OF EXCHANGE TRANSFUSION
Author(s) -
SIGNER M. VEST. E.,
WEISSER K.,
OLAFSSON A.
Publication year - 1970
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1970.tb17705.x
Subject(s) - medicine , exchange transfusion , placebo , double blind , phenobarbital , anesthesia , significant difference , pediatrics , alternative medicine , pathology
SUMMARY In a double blind study the effect of phenobarbitone on neonatal hyperbilirubinaemia and the frequency of exchange transfusion was investigated. Newborn infants admitted were randomly assigned to one of two groups. The treated group comprised 56 and the control group 60 infants. Either placebo solution or phenobarbitone was injected i.m. at 8 hourly intervals for a total of 10 injections. The single dose varied between 1 mg and 5 mg according to weight. One exchange transfusion had to be performed in the treated and 11 in the control group. This difference is statistically significant. Serumbilirubin concentrations from the 4th day on were significantly lower in the treated infants than in controls.