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RELATIONSHIP BETWEEN GLOMERULAR FILTRATION RATE AND RADIOLOGICAL APPEARANCE OF THE RENAL PARENCHYMA IN CHILDREN
Author(s) -
BERG U.,
APERIA A.,
BROBERGER O.,
EKENGREN K.,
ERICSSON N. O.
Publication year - 1970
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1970.tb15506.x
Subject(s) - medicine , renal function , urology , urinary system , renal pelvis , kidney , ureter , parenchyma , nephrectomy , pathology
Summary Selective renal function studies with determination of the glomerular filtration rate (inulin clearance) have been carried out in more than 30 children aged 3 to 15 years. Most of the patients had a history of one or more urinary tract infections as well as pathological IVP‐findings of varying degree. The selective studies were accomplished by means of external ureteral compression. Themethod proved to have an extremely good validity even in cases of severe ureteral reflux with dilatation of ureter and pelvis. No correlation could be found between radiological size of the kidney and glomerular filtration rate. In almost half of the patients with significant unilateral reduction of the renal parenchyma the glomerular filtration rate of this side was found to be more than 40% of the total glomerular filtration rate. In contrast the glomerular filtration rate of several of the kidneys estimated to be of normal size was significantly reduced. It is obvious from these findings that nephrectomy must never be carried out until selective renal function studies have been made. An additional finding was an apparently good correlation between the clinical and functional finding, i.e. the glomerular filtration rate appeared to be inversely correlated to the relapse frequency of the urinary tract infections. The fact that the. functional finding correlated well with the clinical finding but not with the radiological size of the kidney suggests various etiologies for the parenchymal reduction.