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INTRAVASCULAR COAGULATION IN GENERALIZED HERPES SIMPLEX INFECTION OF THE NEWBORN
Author(s) -
SHERSHOW LEE W.,
EKERT HENRY,
SWANSON VIRGINIA L.,
WRIGHT HARRY T.,
GILCHRIST GERALD S.
Publication year - 1969
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1969.tb04756.x
Subject(s) - medicine , disseminated intravascular coagulation , coagulation , simplex , virology , intensive care medicine , mathematics , geometry
Summary A case of disseminated herpes simplex virus infection in a newborn associated with a fatal bleeding diathesis is reported. The presence of intravascular coagulation was suggested by thrombocytopenia, fibrinogenopenia, and reduced Factor V level. At necropsy localized fibrin and platelet deposition was found in liver and lung. It is postulated that intravascular coagulation resulted from local tissue necrosis and the subsequent release of thrombo‐plastin‐like substances into the general circulation. Heparin therapy did not alter the fatal outcome.