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PATHOLOGICAL FEATURES IN THE DE LANGE SYNDROME
Author(s) -
FRANCE N. E.,
CROME L.,
ABRAHAM J. M.
Publication year - 1969
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1969.tb04748.x
Subject(s) - medicine , pathological , thyroid , myelin , pathology , pediatrics , physiology , central nervous system
Summary Two girls with Cornelia de Lange Syndrome, dying at the age of 4 weeks and 9 months respectively, are described. Published examples where necropsy was performed are reviewed and the congenital anomalies of internal organs are summarised. Although some neuropathological features probably result from arrest or retardation of maturation, there was evidence in the younger infant of associated breakdown of myelin. Morphological changes of pituitary, thyroid and adrenal glands, are frequent but no link with hypothalamic lesions has been found.