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URINARY C, 19 AND C 21 STEROID PATTERNS IN ISOSEXUAL PRECOCIOUS PUBERTY DURING LONG‐TERM TREATMENT WITH GESTAGENS
Author(s) -
TELLER W. M.,
MÜRSET G.,
SCHELLONG G.
Publication year - 1969
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1969.tb04735.x
Subject(s) - medicine , excretion , endocrinology , precocious puberty , urinary system , bone age , steroid , physiology , hormone
Summary Five patients (three boys and two girls, aged 1 8 / 12 to 6 years) with idiopathic precocious puberty and one patient (boy, 3 6 / 12 years old) with sexual precocity due to a pinealoma were treated with gestagens, 6α‐methyl‐17α‐acetoxy‐progesterone (Depo‐Provera®) or 6‐chloro‐6‐dehy dro‐17α‐acetoxyprogesterone (Chlormadi‐none acetate; Gestafortin ®), for periods from 4 to 21 months. Before and during treatment the urinary excretion of three 11‐deoxy‐C 19 four 11‐oxy‐C 19 ) and three C 21 steroids was determined by a combined column and paper chromatographic procedure with colorimetric end points. In accordance with the failure of suppression of bone and height ages, the steroid excretion patterns during treatment with Depo‐Provera ® remained essentially unchanged. Even after 21 months of therapy the ratios of 5α/5β of 11‐deoxy C 19 steroids as well as the percentages of allo‐tetrahydrocortisol were elevated above normal ranges. It is concluded that in idiopathic precocious puberty the administration of gestagens fails to inhibit efficiently and J or persistently the secretion of gonadotrophins. They continue to be secreted in amounts sufficient to stimulate endogenous androgen production.