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INCREASING METABOLIC ACIDOSIS FOLLOWING FRUCTOSE INFUSION IN TWO CHILDREN
Author(s) -
ANDERSSON GILLIS,
BROHULT JOHAN,
STERNER GÖRAN
Publication year - 1969
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1969.tb04723.x
Subject(s) - medicine , metabolic acidosis , acidosis , fructose , hypoxia (environmental) , bicarbonate , anesthesia , biochemistry , oxygen , chemistry , organic chemistry
Summary Two children with metabolic acidosis received fructose infusion in accordance with the standard treatment at the time. During the infusion, both pH and bicarbonate decreased in spite of the administration of large doses of bicarbonate. When the fructose infusion was reduced or withdrawn, pH and bicarbonate increased. However, the extreme acidosis (pH 6.6) during fructose infusion in one of the children had probably caused irreversible cell injuries which might have been the main reason for the death in this patient. The other child survived probably because the fructose infusion was interrupted in time. We accordingly recommend that fructose infusions should not be given to patients in whom there is a risk of acidosis and tissue hypoxia.