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STUDIES ON TRYPTOPHAN METABOLISM IN BILHARZIAL HEPATIC FIBROSIS AND NON‐BILHARZIAL HEPATIC CIRRHOSIS IN CHILDHOOD
Author(s) -
ABDELTAWAB G. A.,
KHOLIEF T. S.,
ELSEWEDY S. M.,
ABBASSY A. S.,
ZEITOUN M. M.,
HASSANEIN E. A.
Publication year - 1969
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1969.tb04329.x
Subject(s) - cirrhosis , hepatic fibrosis , medicine , schistosomiasis , gastroenterology , tryptophan , fibrosis , pathology , endocrinology , physiology , immunology , biology , helminths , biochemistry , amino acid
Summary Study on tryptophan metabolism in eight children presenting with bilharzial hepatic fibrosis revealed a pattern reflecting vitamin B 6 deficiency and which could be corrected by supplementing this vitamin. This finding was attributed to S. mansoni infection rather than parenchymal involvement. Similar study carried out on five children with non‐bilharzial hepatic cirrhosis showed low response to a tryptophan load which was not corrected by vitamin B 6 supplementation. The difference between the patterns of tryptophan metabolites in bilharzial fibrosis and non‐bilharzial cirrhosis in children might be due to bilharziasis in the former group and to deranged protein synthesis in the latter.