Premium
IDIOPATHIC APLASTIC ANAEMIA IN CHILDREN
Author(s) -
KILLANDER ANDREAS,
SJOLIN STIG
Publication year - 1969
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1969.tb04323.x
Subject(s) - medicine , prednisone , hypoplasia , pediatrics , disease , surgery , bone marrow , aplastic anemia , aplasia , spontaneous remission , pathology , alternative medicine
Summary The results of treatment of 19 children with idiopathic aplastic anaemia is reported. Initially the patients received testosterone‐prednisone therapy. When a satisfactory haemoglobin level had been reached metandienon was substituted for testosterone and the corticosteroids withheld. 8 patients died without signs of response, 2 patients responded initially but died later. The remaining 9 patients are alive but in only 3 of them was it possible to discontinue all therapy without signs of relapse. The rate of remission varied considerably. One patient required 23 months of combined therapy to achieve a normal haemoglobin level. A moderate hypoplasia of the bone^marrow at the start of therapy was the most favourable prognostic sign in this series. Therefore, it may be concluded that every effort should be made to diagnose the disease before the bone‐marrow changes have progressed to severe hypoplasia.