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STUDIES ON ERYTHRO‐KINETICS IN INFANCY:XII. Survival in Adult Recipients of Cord Blood Red Cells Labelled in Vitro with Di‐isopropyl fluorophosphonate ( DF32P )
Author(s) -
Bratteby LarsEric,
Garby Lars,
Wadman Bengt
Publication year - 1968
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1968.tb07298.x
Subject(s) - cord blood , medicine , in vitro , cord , life span , blood circulation , andrology , immunology , physiology , surgery , biochemistry , biology , gerontology , traditional medicine
Summary Cord blood red cells from 8 full‐term infants were labelled in vitro with di‐iso‐propylfluorophos‐phonate (DF 32 P) and transfused into 8 adult recipients. The disappearance of the labelled cells was slightly curvilinear with a rate of 1.0–1.5% per day during the first month after transfusion and 0.7‐1.0% per day during the following month. The data are discussed with reference to earlier studies and it is concluded that cord blood red cells from full‐term infants disappear from the circulation of adult recipients in much the same way as from the circulation of newborn infants. The finding favours the hypothesis that “intrinsic” rather than “extrinsic” factors are likely to cause the difference in life span between foctal and adult red cells.