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DEVELOPMENT OF NON‐RESPIRATORY COMPONENTS OF ACID‐BASE EQUILIBRIUM IN 250 NORMAL CHILDREN AGED ONE MONTH TO 15 YEARS
Author(s) -
Vokáč Z.,
Vávrová V.
Publication year - 1968
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1968.tb07284.x
Subject(s) - medicine , bicarbonate , base excess , hemoglobin , metabolic acidosis , venous blood , pediatrics , acidosis , respiratory acidosis , respiratory system , acid–base reaction , reference values , acid–base homeostasis , age groups , pco2 , physiology , demography , organic chemistry , sociology , chemistry
Summary Total plasma protein, hemoglobin, standard bicarbonate, buffer base; and base excess concentrations were determined in venous blood of 250 healthy normal children of both sexes aged one month to 15 years. In infants up to one year (100 babies in all) the mean standard bicarbonate concentration was round 21 mEq/1, buffer base 43 mEq/1, and base excess – 4 mEq/1. A slight lowering of the buffering capacity of blood due, above all, to decreased hemoglobin concentration was found in these infants. With increasing age all values come near the normal adult values but do not quite reach them even in the oldest age group of children aged 9 to 15 years. Infants especially, but also children from one to three years of age have, in comparison to adults, a marked trend towards non‐respiratory (metabolic) acidosis that, however, cannot be regarded as pathologic.