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MALIGNANT PHEOCHROMOCYTOMA IN A CHILD: TREATMENT WITH A COMBINATION OF ALPHA‐ AND BETA‐ADRENERGIC BLOCKADE
Author(s) -
Boréus Lars O.,
Broberger Ulf,
Nergårdh Arne,
Zetterqvist Per
Publication year - 1968
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1968.tb07283.x
Subject(s) - medicine , phentolamine , propranolol , pheochromocytoma , blockade , blood pressure , adrenergic , muscle hypertrophy , urinary system , alpha (finance) , anesthesia , endocrinology , surgery , construct validity , receptor , patient satisfaction
Summary A case of inoperable malignant pheochromocytoma in a 9‐year‐old girl is described. On admission to the hospital, the patient was in poor general condition with weight loss, hypertension, a considerable left heart hypertrophy and extremely high concentrations of noradrenaline in central venous blood and urine. Alpha‐adrenergic blockade with phentolamine was insufficient to improve her condition. When the beta‐adrenergic drug, propranolol, was added, a rapid reduction of blood pressure and heart size to normal values occurred with dramatic improvement of the general condition in spite of continued high urinary output of noradrenaline. It is concluded that the symptomatic treatment of pheochromocytoma may require both alpha‐ and beta‐adrenergic blocking drugs for adequate control of the clinical symptoms in this disease.