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THROMBASTHENIA: A STUDY OF TWO SIBLINGS
Author(s) -
Zaizov R.,
Cohen I.,
Matoth Y.
Publication year - 1968
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1968.tb06973.x
Subject(s) - medicine , thrombasthenia , platelet , hemorrhagic diathesis , abnormality , coagulation , fibrinogen , blood platelet disorders , clot retraction , bleeding time , pediatrics , pathology , gastroenterology , platelet aggregation , psychiatry
Summary Clinical and laboratory observations on a brother and sister with congenital hemorrhagic disorder are presented. Both had prolonged bleeding time, poor clot retraction and failure of the platelets to aggregate and adhere to glass in the presence of ADP, absence of platelet extractable fibrinogen and impairment of platelet factor 3 availability. The abnormal platelet function, confirms the recent diagnostic criteria of thrombasthenia. Coagulation studies in the parents were normal. The hemostatic abnormality in thrombasthenia is discussed.