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Growth hormone levels in children during long‐term treatment with corticosteroids
Publication year - 1968
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1968.tb05669.x
Subject(s) - medicine , endocrinology , cortisone , growth hormone , bone age , insulin , growth velocity , hormone
Summary The growth hormone increment induced by hypoglycaemia has been studied in 17 children treated with corticosteroids. No difference in fasting levels was found between normal children and Cortisone‐treated children. An inhibition in HGH release due to insulin‐induced hypoglycaemia was found as well as a correlation between the inhibition of HGH release and dosage of corticosteroids. Furthermore a correlation between mean dose of corticosteroids per year and height increment was observed. The bone age was delayed in nine of the children all of them having high doses of steroids. The mode of the inhibition to HGH release is discussed. Reduced growth is most likely due as well to factors other than inhibition of HGH release. Despite the disadvantage in method of administration, ACTH might be tried more frequently.