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Growth hormone release during insulin tolerance test in normal children
Publication year - 1968
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1968.tb05666.x
Subject(s) - medicine , insulin , endocrinology , hypoglycemia , growth hormone , insulin response , hormone , insulin tolerance test , glucose tolerance test , insulin sensitivity , plasma glucose , insulin resistance
Summary The growth hormone response to insulin‐induced hypoglycemia has been studied in 16 children aged 5 to 15 years. The mean ± S.D. HGH increase during hypoglycaemia was 29.1 ± 11.5 ng/ml which is of approximately the same size as earlier found in adults. The response varied with age of the children, the response being most pronounced in the age groups where growth is accelerated. The results are in agreement with those published by Greenwood (1964) and Parker et al. (1967) but not in agreement with those published by Root et al. (1967) and Kaplan et al. (1968). Differences in HGH standard, immunoassay techniques and amount of insulin used to induce hypoglycaemia are probable explanations for the differences. It is concluded from the results of the present study that a normal response to insulin‐induced hypoglycaemia can be defined as an HGH increase of 10 ng/ml above fasting levels.