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EOSINOPHILIC LEUKEMIA ‐ AN IMMUNOPATHOLOGICAL REACTION?
Author(s) -
Bengtsson Elias
Publication year - 1968
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1968.tb04686.x
Subject(s) - medicine , eosinophilic , spleen , leukemia , pathology , peripheral blood mononuclear cell , lymph , immunology , serology , eosinophilia , antibody , biology , biochemistry , in vitro
Summary An account is given of eosinophilic leukemia in a 5‐year‐old boy, who died after 2 months' illness. Post mortem examination disclosed a large tumor in the thymic region, as well as infiltrates of eosinophilic leukocytes, mainly immature, in the thymus, lymph nodes, spleen, lungs, heart and kidneys. After 3 weeks' illness, the number of atypical mononuclear leukocytes in the peripheral blood increased markedly. This was followed by an increase in the number of eosinophilic leukocytes. Concurrently, a pronounced rise took place in the serological titers for antipneumolysin and Toxoplasma. The mechanism of development of the changes is discussed against the background of a suggested immunopathological process, in which the thymus may have played a central role.