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Antenatal Diagnosis of the Anemia in Erythroblastosis
Author(s) -
FINNE PER HAAVARDSHOLM
Publication year - 1966
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1966.tb15261.x
Subject(s) - medicine , amniotic fluid , erythropoietin , hemoglobin , anemia , obstetrics , pregnancy , fetus , endocrinology , genetics , biology
Summary Spectrophotometry and erythropoietin determinations in the amniotic fluid have been used in the antenatal diagnosis of the anemia in erythroblastosis. An abrupt rise in the erythropoietin level was found when hemoglobin dropped below 11‐10 g. In cases with a milder degree of anemia only a slight or no elevation of erythropoietin levels, compared to normal amniotic fluid, were found. The height of the optical density peak at 450 mp calculated as described by Liley [11] shows a reasonably good correlation to the capillary hemoglobin level a t birth. It is concluded that for routine use spectrophotometric analysis of amniotic fluid is the method of choice.