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The Effect of Prenatal Glucose and Insulin Infusion on Carbohydrate Metabolism in the Newborn
Author(s) -
ZNAMENÁCEK K.,
PŘIBYLOVÁ H.,
ŠABATA V.
Publication year - 1966
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1966.tb15235.x
Subject(s) - medicine , insulin , endocrinology , carbohydrate metabolism , metabolism , anaerobic exercise , acidosis , metabolic acidosis , carbohydrate , physiology
Summary 10 women in labor received a drip infusion of 500 ml of 10% glucose with 16 units of crystalline insulin and further 10 received glucose infusion without insulin, about 30 min. before giving birth. In the newborn infants of these mothers was a continuous fall in the high initial blood glucose values in capillary blood, with significant decrease in ballast excess lactate, without increase in oxygen consumption. It would appear that prenatal infusion of glucose with insulin decreased partially anaerobic metabolism, without increasing the oxidative component. Such an effect might lower the tendency of the newborn to go into metabolic acidosis after birth, and assist the establishment of normal respiration.