Premium
Acid‐Base and Electrolyte Changes during Exchange Transfusion
Author(s) -
BODA D.,
TÓTH GY.,
MURÁNYI L.,
ECK E.
Publication year - 1966
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1966.tb15228.x
Subject(s) - exchange transfusion , medicine , sodium bicarbonate , acidosis , metabolic acidosis , alkalosis , bicarbonate , acid–base reaction , metabolic alkalosis , sodium , anesthesia , chemistry , organic chemistry
Summary In connection with blood exchange transfusions carried out on forty newborn infants it has been found that the majority of the newborns requiring exchange transfusion have metabolic acidosis increasing to possibly critical severity by the end the exchange transfusion. The acidosis, however, is soon normalized spontaneously. Pretreatment with sodium bicarbonate infusion normalizes the pretrans fusion shift in acid‐base balance and vents the development of a severe acidosis following the exchange transfusion without risking a subsequent alkalosis. Before exchange transfusion a slight hypernatraemia has often been observed and this increases transiently after blood exchange. Pretreatment with infusion did not modify this phenomenon. In our material no hyperpotassaemia has been encountered by the end of ex‐ change transfusion. I n response to pre‐treatment with sodium bicarbonate infusion the plasma K + level decreased slightly. By promoting the conjugation of bilirubin to proteins, pretreatment with sodium bicarbonate may presumably improve also the efficiency of the exchange transfusion; this, however, requires further proof.