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A New Method of Pituitary Exploration and Its Use with Children: The Metopirone Test
Author(s) -
LELONG MARCEL,
CANLORBE PIERRE
Publication year - 1963
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1963.tb05522.x
Subject(s) - medicine , hypopituitarism , endocrine system , metyrapone , endocrinology , etiology , pituitary gland , test (biology) , pediatrics , hormone , biology , paleontology
Summary From these observations, it emerges that the Metopirone test is a valuable method of establishing, given an endocrine or metabolic syndrome, the existence of a hypophyseal insufficiency. This appears to us to be of particular interest in pediatrics for a diagnosis of cases of arrested development and dwarfism where a hypophyseal cause often appears possible, but not certain. A negative or diminished response to Metopirone establishes almost invariably the hypothalamo‐hypophyseal origin of retarded growth, though a normal response does not exclude this etiology, for the Metopirone test confirms and specifies the existence in the child of dissociated anterior hypophyseal insufficiencies.