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III. Disappearance from Plasma and Red‐Cell Uptake of Radio‐Active Iron Injected Intravenously 1
Author(s) -
GARBY LARS,
SJÖLIN STIG,
VUILLE JEANCLAUDE
Publication year - 1963
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1963.tb04305.x
Subject(s) - red cell , medicine , iron isotopes , zoology , andrology , endocrinology , kinetics , physiology , biology , isotope , physics , quantum mechanics
Summary The behaviour of intravenously injected radioiron in the plasma and its subsequent appearance in newly formed red cells was investigated in 25 infants aged between 0 and 273 days and in two children aged 591 and 931 days. The data are discussed in relation to previous studies concerning the change in red‐cell production that occurs during this period of life. The data indicate a rapid and profound fall in red‐cell production during the first few days after birth, and a very slow rate of haemoglobin synthesis during the following two months. Subsequently the data indicate an increased rate of red‐cell production. The data obtained during the first two weeks of life have also been analysed in terms of a recently proposed model for ferro‐erythro‐kinetics. The results indicate that the haemoglobin synthesis decreases at a very rapid rate (factor of 15–20) during the first 10 days of life. The absolute amount of haemoglobin synthesis at birth is between 2–3 % per day of the total circulating haemoglobin mass.