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Lipoprotein Lipase in Plasma of the Normal Newborn Preliminary Report
Author(s) -
HÖGSTEDT BIRGITTA,
LINDQUIST BERTIL
Publication year - 1963
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1963.tb04079.x
Subject(s) - lipoprotein lipase , lipase , endocrinology , medicine , lipoprotein , triglyceride , heparin , enzyme , cholesterol , biochemistry , chemistry , adipose tissue
Summary Lipoprotein lipase in plasma after heparin administration has been studied in six newborn infants immediately after birth and in six normal children between the ages of 7 and 17 years. The activity of lipoprotein lipase was, according to the suggestions of Boberg & Carlson [1], evaluated: (1) as the elimination rate of this enzyme from plasma, expressed in terms of half‐life, and (2) as the value for the lipoprotein lipase activity extrapolated at zero time after the heparin injection, expressed in terms of μEq of fatty acids released from a triglyceride substrate, per ml plasma per min. The values for the lipoprotein lipase activity in plasma thus obtained were not appreciably lower in the newborns than in the older children. The elimination rate of the lipoprotein lipase activity amounted in the newborns to 15.4 min and in the older children to 13.3 min (average values); if there was any difference, the elimination of lipoprotein lipase seemed thus to be a little slower in the first‐mentioned group. The implication of these findings is discussed in relation to the possible role of dietary fat as inducer of the production of the production of the lipoprotein lipase enzyme.